About Vinod Patel

Vinod Patel

Consultant (Oral Surgery)
BDS (Hons), MOralSurg RCS (Eng), FDSRCS, MSc, PhD

Profile

Vinod currently works as a consultant at Guys & St Thomas' NHS Foundation Trust and is service lead for dental services in oncology and leads the Bone & Jaw Necrosis Clinic.

Bone & Jaw Necrosis Clinic

A dedicated clinic managing patients 'at risk' and with established jaw necrosis. The clinic has managed over 750 osteonecrosis cases to date. Additionally, we manage patients with similar complex conditions such as osteomyelitis.

Late Effects Clinic

A dedicated clinic managing patients experiencing late effects following chemotherapy and radiation such as mucositis, trismus, xerostomia, neck fibrosis, dysphagia and radiation caries.

Other specialist interests

1. Third molar (wisdom teeth) surgery including coronectomy

2. Peadiatric oral surgery

3. Minimally invasive and medical management of odontogenic tumours

Professional Memberships

Royal College of Surgeons (England)

British Association of Oral & Maxillofacial Surgeons (BAOMS)

British Association Head & Neck Oncology (BAHNO)

European Association of Osseointegration (EAO)

Multinational association of supportive care in cancer (MASCC)

Higher Education Academy (HEA)

Research

PhD

Understanding the impact of intensity modulated radiation on the dental and oral tissues in oropharyngeal cancer patients

Awarded - King's Outstanding PhD Thesis Prize (2021)
Thesis

MSc

External validation of a severe dysphagia prediction model using real world data

Awarded - Pass with merit (Institute of Cancer Research)
Thesis

Grants

Vinod's active grants currently.

1. National Institute of Health Research (research for patient benefit)

A randomised clinical drug trial using pentoxifylline and tocopherol to reduce or avoid radiation changes following head and neck cancer radiotherapy

Other Dental Oncology Research Projects

1. The use of medical management in crainofacial ORN

2. The management of osteonecrosis of the jaw following combined head and neck radiation and bone modifying agents

3. A protocol for dental extractions in patients elevated risk of MRONJ

4. Dental extraction in patients with established or previous MRONJ

5. Outcomes of continuing bone modifying agents in patients with established MRONJ

Collaborative work

1. Prediction of voxelwise mandibular osteonecrosis maps in head and neck cancer using deep learning

2. Use of machine learning for radiation-induced toxicity prediction in head and neck cancer

International collaborative work

Co-collaboration with Professor Bjorn Olsen & Dr Shelley Khullar at Harvard School of Dental Medicine - Tuberculosis related osteonecrosis of the jaw in West Africa

Publications

Dental Oncology Related

The use of pentoxifylline within the medical regime for the management and prevention of osteoradionecrosis in patients with cardiac-, cerebrovascular and thrombo-embolic conditions

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12866

The management of osteoradionecrosis in palliative head and neck cancer patients.

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12867

Pre-existing medication-related osteonecrosis of the jaw before dental extraction.

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/38001199/

The use of liquid formulation pentoxifylline and vitamin E in both established and as a prophylaxis for dental extractions ‘at risk’of osteoradionecrosis.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.

https://pubmed.ncbi.nlm.nih.gov/37316424/

Comparison of machine learning methods for prediction of osteoradionecrosis incidence in patients with head and neck cancer. The British Journal of Radiology

https://pubmed.ncbi.nlm.nih.gov/33684314/

Pembrolizumab-related osteonecrosis of the jaw.

British Journal of Oral and Maxillofacial Surgery

https://pubmed.ncbi.nlm.nih.gov/37957097/

Histopathological insight into a healed case of osteoradionecrosis treated with triple therapy medical management.

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12839

The clinical effect of radiotherapy on pulpal microvasculature: a systematic review

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/36473977/

The microbiota and radiotherapy for head and neck cancer: what should clinical oncologists know

Cancer Treatment Reviews

https://pubmed.ncbi.nlm.nih.gov/35932549/

Osteonecrosis of the jaw in primary dental care: Recognition and referral

Primary Dental Journal

https://pubmed.ncbi.nlm.nih.gov/36073051/

Coronectomy of mandibular third molar in oncology patients

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12709

Pentoxifylline and tocopherol (vitamin E) with/without clodronate for the management of osteoradionecrosis: A scoping review

Oral Diseases

https://pubmed.ncbi.nlm.nih.gov/34695271/

Should the HPV positive oropharyngeal cancer patient be considered for a two-stage dental assessment for their radiation treatment?

Radiotherapy & Oncology

https://pubmed.ncbi.nlm.nih.gov/34624407/

Prophylactic pentoxifylline and vitamin E use for dental extractions in irradiated patients with head and neck cancer

Oral Surg Oral Med Oral Pathol Oral Radiol

https://pubmed.ncbi.nlm.nih.gov/34753695/

Management of laryngeal chondroradionecrosis with pentoxifylline and vitamin E: A case report and review of the literature

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12631

Jaw metastases and the general dental practitioner

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/34824428/

The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 4: miscellaneous cancers

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/35217738/

The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 3: prostate cancer

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/35145242/

The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 2: breast cancer

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/35091612/

The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 1: an overview

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/35027687/

Comparison of machine learning methods for prediction of osteoradionecrosis incidence in patients with head and neck cancer

British Journal of Radiology

https://pubmed.ncbi.nlm.nih.gov/33684314/

Dento-alveolar radiation dose following IMRT in oropharyngeal cancer – an observational study

Special Care Dentistry

https://pubmed.ncbi.nlm.nih.gov/33576541/

A systematic review of metastatic cancer presenting in osteonecrosis of the jaws (MC-ONJ) in patients undergoing antiresorptive and/or antiangiogenic therapy for skeletal-related adverse events

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://pubmed.ncbi.nlm.nih.gov/33518491/

The use of pentoxifylline, tocopherol and clodronate in the management of osteoradionecrosis of the jaws

Radiation & Oncology

https://pubmed.ncbi.nlm.nih.gov/33385466/

Risk factors associated with osteoradionecrosis

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12597

Is there a role for medical management in the treatment of extreme mandibular osteoradionecrosis with pathological fractures?

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12594

The impact of intensity modulated radiation treatment on dento-alveolar microvasculature in pharyngeal cancer implant patients.

Journal of Oral Rehabilitation

https://pubmed.ncbi.nlm.nih.gov/32841377/

Oropharyngeal cancer and osteoradionecrosis in a novel radiation era: A single institution analysis.

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12546

Osteoradionecrosis in the Current Era of Radiation Treatment

Dental Update

https://www.dental-update.co.uk/articleMatchListArticle.asp?aKey=3173

Radiotherapy quadrant doses in oropharyngeal cancer patients treated with intensity modulated radiation therapy

Faculty Dental Journal

https://publishing.rcseng.ac.uk/doi/full/10.1308/rcsfdj.2020.113

A Retrospective Review of Severe Osteoradionecrosis: Risk Factors and Clinical Outcomes

Journal of Oral & Maxillofacial Surgery

https://www.joms.org/article/S0278-2391(17)30755-3/fulltext

A Digitally Generated 3D Dental Model for Assessment of Radiotherapy Doses to the Dentition in Oropharyngeal Cancer Patients for Pre-IMRT Dental Treatment Planning.

Journal of Oral & Maxillofacial Surgery

https://www.joms.org/article/S0278-2391(19)30685-8/fulltext

Prediction of voxelwise mandibular osteoradionecrosis maps in HNC patients using deep learning

Radiotherapy & Oncology

https://www.thegreenjournal.com/article/S0167-8140(19)32349-7/fulltext

Atlas of complication incidence to explore dosimetric contributions to osteoradionecrosis

Radiotherapy & Oncology

https://www.thegreenjournal.com/article/S0167-8140(18)33310-3/fulltext

Presenting dental status of oropharyngeal cancer patients based on HPV status in the IMRT era.

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/32801325/

Deciphering novel chemotherapy and its impact on dentistry

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/32221440/

Pre-radiotherapy presenting dental status of the most common head and neck cancer subsites in a novel radiation era.

Faculty Dental Journal

https://publishing.rcseng.ac.uk/doi/full/10.1308/rcsfdj.2020.52

Presenting pre-radiotherapy dental status of head and neck cancer patients in the novel radiation era

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/32221447/

Medication-related osteonecrosis of the jaw. Guidance for the oncology multidisciplinary team

UK Chemotherapy Board.

https://www.rcplondon.ac.uk/guidelines-policy/medication-related-osteonecrosis-jaw-guidance-oncology-multidisciplinary-team

Osteoradionecrosis beyond the jaws: a mini case series and review of the literature

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12459

Preventing medication-related osteonecrosis of the jaw

British Medical Journal

https://www.ncbi.nlm.nih.gov/pubmed/31068319

Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab-a review

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://www.ncbi.nlm.nih.gov/pubmed/30713092

Pharmacology: MRONJ risk factor

British Dental Journal

https://www.ncbi.nlm.nih.gov/pubmed/29472685

Severe osteonecrosis of the jaw with attempted near mandibular exfoliation

Oral Surgery

https://onlinelibrary.wiley.com/doi/abs/10.1111/ors.12354

Patient reported side effects from liquid pentoxifylline and tocopherol in head and neck radiotherapy patients: An institutional experience and retrospective analysis

Oral Surgery

https://onlinelibrary.wiley.com/doi/abs/10.1111/ors.12337

Osteonecrosis of the jaw unrelated to medication or radiotherapy.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://www.ncbi.nlm.nih.gov/pubmed/29545079

MRONJ risk of adjuvant bisphosphonates in early stage breast cancer.

British Dental Journal

https://www.ncbi.nlm.nih.gov/pubmed/29242516

In-vivo imaging of the microvasculature of the soft tissue margins of osteonecrotic jaw lesions

British Dental Journal

https://www.ncbi.nlm.nih.gov/pubmed/29123273

Methotrexate related jaw necrosis

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://www.ncbi.nlm.nih.gov/pubmed/29056286

Axitinib related jaw necrosis

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://www.ncbi.nlm.nih.gov/pubmed/28918879

The use of piezoelectric surgical debridement in the management of bisphosphonate osteonecrosis of the jaw: a case report

Oral Surgery

https://onlinelibrary.wiley.com/doi/abs/10.1111/ors.12337

The financial burden for the surgical management of osteoradionecrosis

British Dental Journal

https://www.ncbi.nlm.nih.gov/pubmed/28184080

Flapless piezoelectric surgery in the management of jaw necrosis – a case series

Oral Surgery

https://onlinelibrary.wiley.com/doi/abs/10.1111/ors.12262

Use of pentoxifylline and tocopherol in radiation-induced fibrosis and fibroatrophy

British Journal of Oral & Maxillofacial Surgery

https://www.ncbi.nlm.nih.gov/pubmed/28027781

Osteoradionecrosis following treatment for head and neck cancer and the effect of radiotherapy dosimetry: the Guy's and St Thomas' Head and Neck Cancer Unit experience

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://www.ncbi.nlm.nih.gov/pubmed/27039003

Spontaneous Osteonecrosis of the Maxilla

Dental Update

https://www.dental-update.co.uk/issueArticle.asp?aKey=1554

The Prophylactic Use of Pentoxifylline and Tocopherol to Avoid Osteoradionecrosis for Dental Implant Placement in Irradiated Head and Neck Cancer Patients

Journal of Oral & Maxillofacial Surgery

https://www.joms.org/article/S0278-2391(15)00699-0/abstract

Prophylactic use of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of the head and neck

British Journal of Oral & Maxillofacial Surgery

https://www.ncbi.nlm.nih.gov/pubmed/26975577

Use of pentoxifylline and tocopherol in the management of osteoradionecrosis

British Journal of Oral & Maxillofacial Surgery

https://www.ncbi.nlm.nih.gov/pubmed/26794083

New cancer therapies and jaw necrosis

British Dental Journal

https://www.ncbi.nlm.nih.gov/pubmed/26361116

Bisphosphonate osteonecrosis of the jaw--a literature review of UK policies versus international policies on bisphosphonates, risk factors and prevention

British Journal of Oral & Maxillofacial Surgery

https://www.ncbi.nlm.nih.gov/pubmed/20605289

Bisphosphonate osteonecrosis of the jaw: a literature review of UK policies versus international policies on the management of bisphosphonate osteonecrosis of the jaw

British Journal of Oral & Maxillofacial Surgery

https://www.ncbi.nlm.nih.gov/pubmed/20863603

Presentations

2023

National effort for the management of odontogenic tumours

Head & Neck Cancer Foundation - House of Lords

Myth busting in the prevention & management of MRONJ

European Association of Oral Medicine - Annual conference
University of Oslo, Dental Faculty (Oral & Maxillofacial Dept)
Irish Association of Oral Surgeons - Annual conference
Tel-Aviv University Hospital, Dental Faculty
Association of British Academic Oral & Maxillofacial Surgeons
Health Education England, Regional (London/KSS) Spring Conference

Advances in the management of osteoradionecrosis

University of Oslo, Dental Faculty (Oral & Maxillofacial Dept)

Sheba Medical Centre, Tel-Aviv

Osteonecrosis of the jaw – around in the past, seen in the present … and rife in the future?)

Swiss Endodontic Society Annual conference (Geneva)

2022

Myth busting in the prevention & management of MRONJ

British Association of Oral Surgeons

Modern management of paediatric odontongenic tumours and cysts

British Society of Paediatric Dentistry

Pride and prejudice in the treatment of cancer

(Osteonecrosis of the jaw – around in the past, seen in the present … and rife in the future?)

Webb-Johnson Lecture (Royal College of Surgeons, England

2021

Osteoradionecrosis

Swallows charity annual conference

The management of MRONJ

Dental care in cancer study day, Royal College of Surgeons, Edinburgh

Alternative management of odontogenic lesions

Collaborative Head & Neck Academic Group and Project Harar International Webinar Series

Medical management of ORN

UCL Head & Neck Academic Group International Webinar Series

2020

New MRONJ guidance

Chemotherapy Board UK Annual conference

2019

Dental management of oncology patients

Institute of Cancer Research, MSc Oncology (London)

Osteonecrosis of the jaw - around in the past, seen in the present ... and rife in the future?

Cawson's Lecture (Kings College London - Clinical Day) (London)

Non bisphosphonate and denosumab related osteonecrosis of the jaw

MRONJ European Symposium, Copenhagen

2018

Dental management of head and neck radiotherpay patients and novel data

Chirurgie Orale, Chirurgie Maxillo-Faciale et Orthodontie (Paris)

2017

Osteonecrosis of the jaw

British Society of Dental & Maxillofacial Radiologist Conference (London)

2015

Jaw necrosis clinical pathway

London Cancer Alliance (London)

The prophylatic use of pentoxifylline and tocopherol for dental implant placement in irradiated head and neck oncology patients

American Association of Oral & Maxillofacial Surgery Conference (Washington)

Wider clinical and research activity

Publications

The continuation of oral anticoagulation and antiplatelet therapy for dento-alveolar surgery: a service evaluation.

British Dental Journal.

https://pubmed.ncbi.nlm.nih.gov/37684457/

Oral Surgery: what challenges and opportunities are there on the horizon.

Dental Update

https://www.dental-update.co.uk/content/oral-surgery/oral-surgery-what-challenges-and-opportunities-are-there-on-the-horizon/

Outcomes of microsurgical free tissue transfer performed on international surgical collaborations in low-income and middle-income countries: A systematic review and meta-analysis. Journal of Plastic, Reconstructive & Aesthetic Surgery.

https://pubmed.ncbi.nlm.nih.gov/35490120/

Long-term outcomes of mandibular reconstruction using non-vascularised rib grafts following large ameloblastoma resections in Ethiopia

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12699

A case of severe odontogenic infection in Kikuchi-Fujimoto disease

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12680

The impact of the COVID-19 pandemic on international reconstructive collaborations in Africa

European Journal of Plastic Surgery

https://pubmed.ncbi.nlm.nih.gov/34629757/

Protocol for a systematic review of outcomes from microsurgical free-tissue transfer performed on short-term collaborative surgical trips in low-income and middle-income countries

Systematic reviews

https://pubmed.ncbi.nlm.nih.gov/34496948/

A Difficult Diagnosis of Spontaneous Lower Lip Numbness

Dental Update

https://www.dental-update.co.uk/articleMatchListArticle.asp?aKey=3299

Diffuse sclerosing osteomyelitis of the mandible: a case-report following the treatment over a 12 year period

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12639

Improving smartphone follow-up after patient discharge from annual short-term head and neck missions in Ethiopia

Journal of Plastic, Reconstructive & Aesthetic Surgery

https://pubmed.ncbi.nlm.nih.gov/33865728/

Pharmacological management of an aneurysmal bone cyst in Noonan

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12615

Sickle Cell Osteomyelitis: A novel approach and review of the literature

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12587

Smartphones can be used for patient follow-up after a surgical mission treating complex head and neck disfigurement in Ethiopia: Results from a prospective pilot study

Journal of Plastic, Reconstructive & Aesthetic Surgery

https://pubmed.ncbi.nlm.nih.gov/33189622/

Real-Time Optical Vascular Imaging, a new method for the diagnosis and monitoring of oral diseases

Journal of Microscopy

https://pubmed.ncbi.nlm.nih.gov/33119132/

Adjuvant Alendronic Acid in the Management of Severe Cherubism: A Case Report and Literature Review

Journal of Oral & Maxillofacial Surgery

https://pubmed.ncbi.nlm.nih.gov/33159843/

High-Tension Closure of the Submental Flap Donor Site: Video and Technical Considerations

Plastic & Reconstructive Surgery Global Open

https://pubmed.ncbi.nlm.nih.gov/33425586/

Short-term surgical missions to resource-limited settings in the wake of the COVID-19 pandemic

Journal of Plastic, Reconstructive & Aesthetic Surgery

https://pubmed.ncbi.nlm.nih.gov/32891553/

Mycobacterial and Plasmodium ovale-associated destruction of the jaw bones.

Oral Diseases

https://pubmed.ncbi.nlm.nih.gov/33325564/

The role of antiresorptive drugs and medication related osteonecrosis of the jaw in nononcologic immunosuppressed patients: a systematic review

Journal of Research in Medical Sciences

https://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=23;epage=23;aulast=Sacco

Short-term surgical missions to resource-limited settings in the wake of the COVID-19 pandemic

Journal of Plastic, Reconstructive and Aesthetics Surgery

https://pubmed.ncbi.nlm.nih.gov/32891553/

Secondary chronic osteomyelitis of the mandible: A resistant disease successfully treated with bisphosphonate therapy

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12578

Dentigerous cyst; a rapidly expanding swelling in a young patient

Dental Update

(in press)

Immediate Dental Implant Placement Following Sinus Elevation in Maxillary Bone Levels Less Than 6mm.

Journal of Oral & Maxillofacial Surgery

https://www.joms.org/article/S0278-2391(17)30821-2/fulltext

A Review of 120 Coronectomy Root Retrievals

Journal of Oral & Maxillofacial Surgery

https://www.joms.org/article/S0278-2391(19)30679-2/fulltext

Barriers to Obtaining Informed Consent on Short-term Surgical Missions.

Plastics and Reconstructive Surgery - Global open

https://journals.lww.com/prsgo/fulltext/2020/05000/barriers_to_obtaining_informed_consent_on.31.aspx

Provision of dental services at a single institution in the UK’s Epicentre during the COVID-19 Pandemic

British Dental Journal

https://pubmed.ncbi.nlm.nih.gov/32591713/

Long-term outcomes associated with short-term surgical missions treating complex head and neck disfigurement in Ethiopia: A retrospective cohort study

Journal of Plastic and Reconstruction Aesthetic Surgery

https://pubmed.ncbi.nlm.nih.gov/32063454/

Diffuse sclerosing osteomyelitis: A case series and literature review

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://pubmed.ncbi.nlm.nih.gov/32102763/

Coronectomy root retreivals: A review of 92 cases

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

https://www.ncbi.nlm.nih.gov/pubmed/30309828

Cryotherapy for the management of a lip lymphangioma - a case report and literature review

Oral Surgery

https://onlinelibrary.wiley.com/doi/10.1111/ors.12400

Identifying the Polo Mint mandibular third molar